MiBiotix PP Premium Plus with MegasporeBiotic - the 1st probiotic to PROTECT its human host

Among non-communicable diseases, intestinal permeability (metabolic endotoxemia) is the #1 cause of morbidity and mortality worldwide. Metabolic endotoxemia is a condition that stems from dysbiosis and a breakdown of intestinal barrier function. Intestinal permeability is present in most chronic diseases and is believed to be a major driver of many conditions. MegaSporeBiotic is clinically shown to reduce intestinal permeability by 60%, when compared to the placebo control group, in just 30 days without any additional interventions.

Reduce LPS Translocation
Reduce Systemic Inflammation
Repair Leaky Gut

Conditions associated with Metabolic Endotoxemia/Intestinal Permeability:

  • Autoimmunity
  • Depression
  • Anxiety 
  • Alzheimer’s
  • Memory Loss
  • Anorexia
  • Parkinson’s
  • Hypogonadism
  • Leptin Resistance
  • Chronic Pain

MegaSporeBioticTM is formulated with nature in mind. Found naturally in the environment for millions of years, Bacillus spores have developed a symbiotic relationship with their human host. Our ancestors derived probiotic benefits from inadvertently consuming bacillus spores on a regular basis. In fact, the oldest bacterial spore ever documented was 250 million years old and found inside salt crystals in Carlsbad, New Mexico. Though it sounds like science fiction, scientists were actually able to isolate and grow the 250-million-year-old spores!

Bacillus spores are naturally designed to survive digestion. The reason for their inherent survivability comes from the spores’ bi-phasic life cycle. This means that the Bacillus spores can transition interchangeably from their dormant form to their active form, depending on the environment. In its dormant spore form, Bacillus will surround itself with an endospore, which is a tough, natural outer shell that protects it from light, heat, pressure, acid, lack of oxygen, and other environmental factors. This key feature is what allows MegaSporeBioticTM to survive easily through digestion without the need for enteric-coated capsules. In fact, MegaSporeBioticTM maintains its viability outside of its capsule and can even survive baking, up to 450 ̊ F.

Over 70% of the immune system can be found in the gut in the form of gut-associated lymphoid tissue, or GALT. Studies show that Bacillus subtilis promotes the development of GALT, which is critical to the formation of a properly functioning and robust immune system. MegaSporeBioticTM also supports the immune system by stimulating Peyer’s patches, as well as Toll-like receptors, in order to improve pattern recognition, increase circulating T and B lymphocytes, and upregulate regulatory T cells. The end result is a healthier gut lining and a stronger immune system that is better equipped to handle unfavorable lifestyle and environmental factors that can lead to conditions like asthma, allergies, autoimmunity, and infections.

Leaky Gut Syndrome, a condition characterized by increased intestinal permeability, has become a major problem in the United States. Some studies even suggest that leaky gut plays a pivotal, and perhaps even causal, role in the development of many chronic diseases by triggering low-grade systemic inflammation. On the cellular level, leaky gut is the result of disrupted tight junctions between colonocytes, creating small holes in the protective intestinal wall. These small openings allow unwanted toxins to pass through the intestinal wall directly into the bloodstream, where they can increase inflammation. MegaSporeBioticTM has been shown to heal leaky gut by closing tight junctions between colonocytes, increasing the thickness of intestinal mucosa, and up-regulating secretory IgA levels that support the body’s natural defense against infections. With a published, human clinical trial showing a 60% reduction in leaky gut in just 30 days, MegaSporeBioticTM is the most effective leaky gut solution on the market today.

Most Probiotics
MegaSpore Biotic
Predominant Species
Lactobacillus | Bifidobacteria
Reseed the gut
Recondition the gut
Most do not survive digestion
Designed to survive digestion
All humans have binding sites for bacillus
Effective colonization in the human gut
Few companies DNA verify their probiotics
Subject to 3rd party DNA verification
Efficacy with antibiotics
Most probiotcs are destroyed by antibiotics
Strong enough to withstand broad-spectrum antibiotics
Clinically shown to reduce intestinal permeability
Ask us about our Leaky Gut study
Clinically shown to reduce serum cholesterol and triglycerides
Ask us about our Cholesterol study
Provides powerful immune support
Ask us about our Pre-Autoimmune study

The Missing Link

Spore-based probiotics are much more effective than conventional probiotics on the market because they are designed to survive through the harsh gastric system, colonize, and increase microbial diversity in the gut. Because these spores are so multi-functional, they maintain their efficacy for a broad spectrum of conditions. A mega-dose, spore formula with broad-spectrum activity has only been available for the past few decades as a pharmaceutical drug in Europe – until now. MegaSporeBiotic is the first mega-dose, multi-spore probiotic available as a dietary supplement. A culmination of published research shows that the spores found in MegaSporeBiotic can support healthy function with a variety of health conditions.

Inhibits LPS from accumulating in the brain, where it can damage neurons and increase inflammation

Supports a healthy immune response to the environment and food. Spores have the ability to interact with and modulate the immune system.

Supports healthy gut flora that are more resistant to unwanted overgrowths

Reduces circulating LPS associated with a variety of endocrine imbalances.

Balances the gut microbiome which controls the bladder microbiome

Reduces circulating LPS levels, shown to have a disruptive effect on serotonin and dopamine function.

Supports healthy inflammatory response and healthy triglyceride balance.

Seals up the gut in just 30 days!

Increases butyrate production, which has been shown to reduce the inflammatory process in the gut.

Reduces elevated LPS levels to support healthy skin.

What’s in MegaSporeBiotic?


    R1,099.22 available on subscription
    Rated 5.00 out of 5
Frequently Asked Questions

Q: What is the shelf life of MegaSporeBiotic?
5 Years. The expiration date will be indicated on the bottle.

Q: What is the source of bacterial strains found in MegaSporeBiotic?
The original bacterial strains were isolated from healthy human subjects. They are kept in a bacteria bank at London University Royal Holloway. When it is time for production, the bacteria are checked again for proper characterization and DNA verified to be the strains we require. Those strains are shipped individually to our pharmaceutical-grade facility, where they are grown to the quantities we require and then shocked back into their spore form for 100% spore delivery. The final product then undergoes 3rd party DNA verification to ensure that it meets label claims.

Q: Is this a soil-based probiotic?
No. Although the strains found in MegaSporeBiotic can survive in the soil, they are not soil-based organisms (SBOs) – organisms that are meant to thrive in the soil. Unlike SBOs, the strains in MegaSporeBiotic are natural, gut commensal organisms that are meant to thrive in the human gut. Some SBOs can withstand the harsh environment of the digestive tract, but they are not built to thrive in the human gut.

Q: Why are there only 4 billion CFUs in MegaSporeBiotic? I thought you wanted at least 20 billion CFUs?
There is actually no scientific data to support the idea that probiotics with higher CFUs are more effective. In fact, many of these probiotics contain Lactobacillus or Bifidobacter, which tend to die off during digestion. Because the human gut naturally contains trillions of these species, you would need to supplement with trillions of Lactobacillus or Bifidobacter to see a noticeable improvement in immune function. Bacillus species, on the other hand, only exist in the human gut around 10 million CFUs, so we see a noticeable improvement by supplementing with 4 billion CFUs.

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