Bacillus spores are naturally designed to survive digestion. The reason for their inherent survivability comes from the spores’ bi-phasic life cycle. This means that the Bacillus spores can transition interchangeably from their dormant form to their active form, depending on the environment. In its dormant spore form, Bacillus will surround itself with an endospore, which is a tough, natural outer shell that protects it from light, heat, pressure, acid, lack of oxygen, and other environmental factors. This key feature is what allows MegaSporeBioticTM to survive easily through digestion without the need for enteric-coated capsules. In fact, MegaSporeBioticTM maintains its viability outside of its capsule and can even survive baking, up to 450 ̊ F.

Over 70% of the immune system can be found in the gut in the form of gut-associated lymphoid tissue, or GALT. Studies show that Bacillus subtilis promotes the development of GALT, which is critical to the formation of a properly functioning and robust immune system. MegaSporeBioticTM also supports the immune system by stimulating Peyer’s patches, as well as Toll-like receptors, in order to improve pattern recognition, increase circulating T and B lymphocytes, and upregulate regulatory T cells. The end result is a healthier gut lining and a stronger immune system that is better equipped to handle unfavorable lifestyle and environmental factors that can lead to conditions like asthma, allergies, autoimmunity, and infections.

Leaky Gut Syndrome, a condition characterized by increased intestinal permeability, has become a major problem in the United States. Some studies even suggest that leaky gut plays a pivotal, and perhaps even causal, role in the development of many chronic diseases by triggering low-grade systemic inflammation. On the cellular level, leaky gut is the result of disrupted tight junctions between colonocytes, creating small holes in the protective intestinal wall. These small openings allow unwanted toxins to pass through the intestinal wall directly into the bloodstream, where they can increase inflammation. MegaSporeBioticTM has been shown to heal leaky gut by closing tight junctions between colonocytes, increasing the thickness of intestinal mucosa, and up-regulating secretory IgA levels that support the body’s natural defense against infections. With a published, human clinical trial showing a 60% reduction in leaky gut in just 30 days, MegaSporeBioticTM is the most effective leaky gut solution on the market today.